Opportunities @ SPARC

How would you describe this position in 2-3 lines? This role requires relevant skillset to conduct multi step synthesis, purification and analytical characterization of drugs like organic compounds to support execution of Medicinal chemistry plans. A scientific mind set, passion for chemistry, alliance to corporate work culture and team spirit are what we are looking in the ideal candidate.   What are the key responsibilities of the role?

• On – bench independent execution of medicinal chemistry plans including new and repeat synthesis of NCEs, scale up of Intermediates and NCEs, troubleshooting with new synthetic routes.
• Interpret spectral data of synthesized compounds
• Be part of a focused research team under the Dept of Medicinal Chemistry at SPARC Drug Discovery located at Savli, Vadodara.
• Maintain Lab safety norms and also be part of the team to manage inventory of chemicals and pro-actively manage sourcing/ordering.
• Documentation of laboratory work (Reaction set up, work-up, purification, Analytical characterization, ELN maintenance, Experimental write-up).

  Key Skills and Requirements

• MSc in Chemistry with specialization in Organic Chemistry / Drug Chemistry / Medicinal chemistry from premier Institutes with result of 1st class / >60% / CGPA >7.5.
• At least 2 to 5 years of research experience in synthetic organic chemistry from Academic Labs / relevant Pharma R&D e.g., Drug Discovery or MedChem CRO set up.
• Should have basic knowledge of functional group transformation in the core area of synthetic organic and heterocyclic chemistry.
• Experience in using chemistry drawing and ELN (electronic laboratory notebooks) systems.

 

How would you describe this position in 2-3 lines? Thought leader with experience in Oncology drug discovery and development. Lead a team of researchers to support project related activities in in vitro biology entailing new assay design, screening, and interpretation of results, generation of new ideas and new target identification and validation. The role requires extensive cross-functional collaboration and liaising with internal and external stakeholders. What are the key responsibilities of the role?

• Propose new ideas, conduct and assist in target evaluations & due diligences.
• Oversee in vitro screening experiments and generate reports in a timely manner.
• Independently design and execute new assays/platform technologies to support screening activities and mechanistic characterization.
• Effectively coordinate inter-departmental communication to facilitate timely execution of tasks and data communication. Present key finding in project team meetings, and to senior management or KOLs.
• Mentor and train group members to facilitates their professional growth.
• Ability to work in a fast paced, cross-functional, flexible and team-oriented environment.
• Oversee routine lab-related activities.

Key Skills and Requirements

• PhD – Life Sciences.
• At least 10 to 14 years in the drug discovery and development research division with expertise in the field of oncology.
• Overall understanding of disease biology and pathways to facilitate drug discovery.
• Familiarity with multiple and diverse bioassay techniques for study of enzymes, kinases, GPCR’s, RNA binding proteins, epigenetic targets etc.
• Proven expertise in moving assets in oncology through hit to lead to candidate stages.
• Hands-on experience in mammalian cell culture, molecular biology, cell-based assays of various types, binding assays, enzymatic assays, ELISA, HTRF, identification of biomarkers etc.
• Equally comfortable with cell-based and biochemical assays.
• Clear understanding of assay validation parameters, and statistical data analysis.
• Exposure to molecular biology and recombinant DNA technology, stable cell line generation, and gene knockdown and knockout experiments.

Competencies

• Detail oriented with ability to manage multiple tasks.
• Qualification and validation of bioassays.
• Preparation of technical reports and IND supporting document.
• Proficient in using - GraphPad, MS excel, MS word, MS PowerPoint.
• Excellent interpersonal skills required to manage personnel & timelines and coordinate activities with cross functional experts and effective communication skills.
• Ability to lead a team of 4-8 people. Demonstrated and proven managerial abilities for the same.